Generic Name: morphine (MOR feen)
Brand Names: AVINza, Kadian, Morphine IR, MS Contin, MSIR, Oramorph SR, Roxanol
What is Oramorph SR (morphine)?
Morphine is a narcotic pain reliever.
Morphine is used to treat moderate to severe pain. Short-acting morphine is taken as needed for pain. Extended-release morphine is for use when around-the-clock pain relief is needed.
Morphine is not for treating pain just after surgery unless you were already taking morphine before the surgery.
Morphine may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Oramorph SR (morphine)?
You may not be able to take this medicine unless you are already being treated with a similar opioid pain medicine and your body is tolerant to it. Talk with your doctor if you are not sure you are opioid-tolerant.
Morphine may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it. Do not drink alcohol while you are using morphine. Dangerous side effects or death can occur when alcohol is combined with morphine. Check your food and medicine labels to be sure these products do not contain alcohol.
Never take morphine in larger amounts, or for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.
Do not stop using morphine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using morphine.
What should I discuss with my healthcare provider before using Oramorph SR (morphine)?
Do not use this medicine if you have ever had an allergic reaction to a narcotic medicine (examples include methadone, morphine, Oxycontin, Darvocet, Percocet, Vicodin, Lortab, and many others), or to a narcotic cough medicine that contains codeine, hydrocodone, or dihydrocodeine. You should also not take morphine if you are having an asthma attack, or if you have a bowel obstruction called paralytic ileus. Do not use morphine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.
To make sure you can safely take morphine, tell your doctor if you have any of these other conditions:
a blockage in your digestive tract (stomach or intestines);
asthma, COPD, sleep apnea, or other breathing disorders;
- liver or kidney disease;
underactive thyroid;
curvature of the spine;
a history of head injury or brain tumor;
epilepsy or other seizure disorder;
low blood pressure;
gallbladder disease;
Addison's disease or other adrenal gland disorders;
enlarged prostate, urination problems;
mental illness; or
a history of drug or alcohol addiction.
You may not be able to take morphine unless you are already being treated with a similar opioid pain medicine and your body is tolerant to it. Talk with your doctor if you are not sure you are opioid-tolerant. Morphine may be habit forming and should be used only by the person it was prescribed for. Never share morphine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. FDA pregnancy category C. It is not known whether morphine will harm an unborn baby. Morphine may cause addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using morphine. Morphine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Older adults and those who are ill or debilitated may be more likely to have serious side effects.
How should I use Oramorph SR (morphine)?
Take exactly as prescribed. Never take morphine in larger amounts, or for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.
Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It will release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.
To make swallowing easier, you may open the extended-release capsule and sprinkle the medicine into a spoonful of applesauce. Swallow this mixture right away without chewing. Do not save the mixture for later use. Discard the empty capsule.
Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Do not stop using morphine suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication. Store this medication at room temperature, away from heat, moisture, and light.
Keep track of how many pills have been used from each new bottle of this medicine. Morphine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.
Always check your bottle to make sure you have received the correct pills (same brand and type) of medicine prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.
After you have stopped using this medication, flush any unused pills down the toilet. Throw away any unused liquid morphine that is older than 90 days.
What happens if I miss a dose?
Since morphine is sometimes used as needed, you may not be on a dosing schedule. If you are using the medication regularly, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.
Extended-release morphine is not for use on an as-needed basis for pain.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of morphine can be fatal.
Overdose symptoms may include extreme drowsiness, pinpoint pupils, confusion, cold and clammy skin, weak pulse, shallow breathing, fainting, or breathing that stops.
What should I avoid while using Oramorph SR (morphine)?
Do not drink alcohol while you are taking this medication. Dangerous side effects or death can occur when alcohol is combined with morphine. Check your food and medicine labels to be sure these products do not contain alcohol. This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Oramorph SR (morphine) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
shallow breathing, slow heartbeat;
seizure (convulsions);
cold, clammy skin;
confusion;
severe weakness or dizziness; or
feeling light-headed, fainting.
Less serious side effects may include:
constipation;
warmth, tingling, or redness under your skin;
nausea, vomiting, stomach pain, diarrhea, loss of appetite;
dizziness, headache, anxiety;
memory problems; or
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Oramorph SR (morphine)?
Do not take morphine with any other narcotic pain medications, sedatives, tranquilizers, sleeping pills, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.
Tell your doctor about all other medicines you use, especially:
cimetidine (Tagamet);
buprenorphine (Buprenex, Subutex);
butorphanol (Stadol);
nalbuphine (Nubain);
pentazocine (Talwin); or
a diuretic (water pill).
This list is not complete and other drugs may interact with morphine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More Oramorph SR resources
- Oramorph SR Side Effects (in more detail)
- Oramorph SR Use in Pregnancy & Breastfeeding
- Drug Images
- Oramorph SR Drug Interactions
- Oramorph SR Support Group
- 3 Reviews for Oramorph SR - Add your own review/rating
- Oramorph SR Prescribing Information (FDA)
- Oramorph SR Advanced Consumer (Micromedex) - Includes Dosage Information
- Oramorph SR Sustained-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)
- Morphine Concentrate MedFacts Consumer Leaflet (Wolters Kluwer)
- Astramorph PF Solution MedFacts Consumer Leaflet (Wolters Kluwer)
- Astramorph PF Prescribing Information (FDA)
- Astramorph PF Advanced Consumer (Micromedex) - Includes Dosage Information
- Avinza Extended-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)
- Avinza Consumer Overview
- Avinza Prescribing Information (FDA)
- Infumorph Solution MedFacts Consumer Leaflet (Wolters Kluwer)
- Kadian Consumer Overview
- Kadian Extended-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)
- Kadian Prescribing Information (FDA)
- MS Contin Consumer Overview
- MS Contin Prescribing Information (FDA)
- Morphine Sulfate Monograph (AHFS DI)
- RMS Suppositories MedFacts Consumer Leaflet (Wolters Kluwer)
Compare Oramorph SR with other medications
- Pain
Where can I get more information?
- Your pharmacist can provide more information about morphine.
See also: Oramorph SR side effects (in more detail)
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